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HEALTH-VIRUS-NOVAVAX-VACCINE
Novavax Covid vaccine highly effective, but not against S.Africa variant
WASHINGTON, Jan 29, 2021 (BSS/AFP) – US biotech firm Novavax said Thursday
its two-shot Covid-19 vaccine showed an overall efficacy of 89.3 percent in a
major Phase 3 clinical trial in Britain, and remained highly effective
against a variant first identified there.
But the positive news was partly offset by other results that showed it
offered significantly less protection against a highly transmissible variant
of the coronavirus first identified in South Africa, which is spreading
rapidly around the world.
Novavax said it began working on new vaccines against emerging strains in
early January and expects to select ideal candidates in the coming days, then
begin clinical testing in the second quarter of the year.
“NVX-CoV2373 has the potential to play an important role in solving this
global public health crisis,” said the company’s president and CEO Stanley
Erck, using Novavax’s name for the vaccine.
“We look forward to continuing to work with our partners, collaborators,
investigators and regulators around the world to make the vaccine available
as quickly as possible.”
British Prime Minister Boris Johnson tweeted that the results were “good
news.”
“Our medicines regulator will now assess the vaccine, which will be made in
Teesside. If approved, we have 60m doses on order,” he added.
The vaccine was one of six candidates backed by a US government project
formerly known as Operation Warp Speed, which has provided the company $1.75
billion. It’s also being tested in a trial in the US and Mexico, which has
recruited 16,000 of 30,000 participants.
Unlike the Pfizer, Moderna and AstraZeneca vaccines, which deliver the
genetic instructions that make human cells create a key protein of the virus,
the Novavax shot injects the proteins directly into the body to evoke an
immune response.
– ‘Still pretty good’ against B.1.351 –
The British trial involved 15,000 people aged 18 to 84, including 27
percent who were over the age of 65.
The first interim analysis was based on 62 cases, of which 56 cases of
Covid-19 were observed in the placebo group versus six cases among people who
received NVX-CoV2373.
The company’s preliminary analysis indicated the variant first identified
in Britain, B.1.1.7, was detected in more than 50 percent of the confirmed
cases.
Efficacy by strain was calculated at 95.6 percent against the original
Covid strain, and 85.6 percent against B.1.1.7.
But the level of protection was lower in a smaller, mid-stage trial
conducted in South Africa.
This study enrolled just over 4,400 patients from September to mid-January,
during which time the B.1.351 variant, which contains critical mutations
along the virus’ spike protein, was spreading rapidly through the country.
Overall efficacy was 49.4 percent in this trial, but the figure rose to 60
percent among the 94 percent of trial participants who were HIV-negative.
Worryingly, Novavax said about a third of participants in the South Africa
trial had been previously infected with the original form of the virus, while
the subsequent infections during the study were largely from the variant.
Amesh Adalja, a doctor and senior scholar at the Johns Hopkins Center for
Health Security, told AFP it was important to keep the decreased efficacy in
perspective and the vaccine was still a success.
“Sixty percent against the variant is still pretty good,” he said.
“Clearly, the Novavax vaccine prevented severe disease which is really in the
end what matters the most.”
– J&J next? –
The studies are the first to assess a Covid-19 vaccine’s performance
against both the UK and South Africa variants in the real world.
Pfizer and Moderna have previously said their vaccines remain effective
against the variants, but their studies were based on lab research.
The US said Thursday it had found its first two cases of the B.1.351
variant on American soil, leading to concern it could reignite the national
infection rate, which is currently in decline.
Novavax’s announcement puts pressure on another vaccine maker, Johnson &
Johnson, which is expected to announce its phase 3 trial results next week.
BSS/AFP/GMR/0930 hrs