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HEALTH-GENETICS-INFANTS-FATHER
Older dads’ kids run higher health risks at birth: study
PARIS, Nov 1, 2018 (BSS/AFP) – Newborns of fathers 45 and older are more
likely to be underweight or wind up in intensive care, researchers reported
Thursday, adding to the list of problems associated with older dads.
For fathers 55 and up, infants tended to score worse in a standardised test
used to assess the baby’s health immediately after birth.
Even more startling — and harder to explain — was a heightened risk for
women carrying the child of a man 55 and older of diabetes arising during
pregnancy, according to a study published in the medical journal BMJ.
All these conclusions, the researchers cautioned, are based on an analysis
of medical records rather than a controlled experiment, which means no firm
conclusions about cause-and-effect can be drawn.
The overall risk of such outcomes also remained low, they added.
But the findings held true even after other factors that might skew the
results — age of the mother, maternal smoking, level of education — were
taken into account, they said.
“A significant number of these negative birth outcomes were estimated to be
prevented if older fathers had elected to have children before the age of
45,” the scientists concluded.
“The risk associated with advanced paternal age should be included in
discussions regarding family planning and reproductive counselling.”
The average age of fatherhood has been steadily rising in wealthy nations,
as has the percentage of fathers above 45 or 55.
In the United States, the number of births to men 40 and older has almost
doubled to nine percent over the last 40 years. For men over 50, the
percentage has gone up from 0.5 to nearly one.
– 20 grammes lighter –
Similar trends are found in western Europe. In England, for example,
fathers over 35 accounted for 40 percent of all births in 2003, compared with
25 percent in 1993.
To date, most research on the link between the age of parents and health
outcomes in children has focused on older mothers.
But recent studies suggest that being a father later in life may also be
associated with higher risks in offspring of autism, genetic abnormalities
and mental problems.
One possible culprit is thought to be changes with age in male reproductive
cells that affects the way genes are expressed, rather than the genes
themselves.
To better understand the possible impact of advanced-age fatherhood on
infants and mothers, researchers led by Michael Eisenberg of Stanford
University combed through data on more than 40.5 million births in the United
States from 2007 to 2016.
Children born of fathers 45 or older were on average 20 grammes lighter,
and had a 14 percent higher risk of low birth weight — less than 2.5 kilos
(5.5 pounds) — than infants born to younger dads.
These children were also 14 percent more likely to be admitted to a
neonatal intensive care unit, and had 18 percent higher odds of experiencing
a seizure compared with infants of fathers aged 25 to 34.
The risk of gestational diabetes, meanwhile, for women carrying the child
of a man aged 55 or older increased by 34 percent.
The researchers further estimate that 13 percent of premature births were
attributable to fathers of more advanced age.
BSS/AFP/MSY/1236 hrs